Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS). Surface adenosine receptors trigger cyclic AMP (cAMP) formation in neutrophils, and this mechanism ha...

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Udgivet i:Nat Commun
Main Authors: Ali, Ramadan A., Gandhi, Alex A., Meng, He, Yalavarthi, Srilakshmi, Vreede, Andrew P., Estes, Shanea K., Palmer, Olivia R., Bockenstedt, Paula L., Pinsky, David J., Greve, Joan M., Diaz, Jose A., Kanthi, Yogendra, Knight, Jason S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478874/
https://ncbi.nlm.nih.gov/pubmed/31015489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09801-x
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