SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles

Primordial follicles, consisting of granulosa cell (GC)-enveloped oocytes are maintained in a state of developmental arrest until activated to grow. The mechanism that operates to maintain this arrested state in GCs is currently unknown. Here, we show the TGFβ-activated transcription factor SMAD3 is...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Granados-Aparici, Sofia, Hardy, Kate, Franks, Stephen, Sharum, Isam B., Waite, Sarah L., Fenwick, Mark A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478827/
https://ncbi.nlm.nih.gov/pubmed/31015579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42878-4
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