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A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or only very weakly, recruit beta-arrestin. Devel...
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| Pubblicato in: | Front Pharmacol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478756/ https://ncbi.nlm.nih.gov/pubmed/31057409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00407 |
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