SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

Intermittent food deprivation (fasting, IF) improves mood and cognition and protects neurons against excitotoxic degeneration in animal models of epilepsy and Alzheimer’s disease (AD). The mechanisms by which neuronal networks adapt to IF and how such adaptations impact neuropathological processes a...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Liu, Yong, Cheng, Aiwu, Li, Yu-Jiao, Yang, Ying, Kishimoto, Yuki, Zhang, Shi, Wang, Yue, Wan, Ruiqian, Raefsky, Sophia M., Lu, Daoyuan, Saito, Takashi, Saido, Takaomi, Zhu, Jian, Wu, Long-Jun, Mattson, Mark P.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478744/
https://ncbi.nlm.nih.gov/pubmed/31015456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09897-1
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