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Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model

BACKGROUND: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder caused by heterozygous, loss-of-function mutations in four TGFβpathway members, including the central transcriptional mediator of the TGFβ pathway, Smad4. Loss of Smad4 causes the formation of inapprop...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Crist, Angela M., Zhou, Xingyan, Garai, Jone, Lee, Amanda R., Thoele, Janina, Ullmer, Christoph, Klein, Christian, Zabaleta, Jovanny, Meadows, Stryder M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478529/
https://ncbi.nlm.nih.gov/pubmed/30744395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.036952
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