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Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder that leads to abnormal connections between arteries and veins termed arteriovenous malformations (AVM). Mutations in TGFβ pathway members ALK1, ENG and SMAD4 lead to HHT. However, a Smad4 mouse model of HHT does n...

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Detalhes bibliográficos
Publicado no:Angiogenesis
Main Authors: Crist, Angela M., Lee, Amanda R., Patel, Nehal R., Westhoff, Dawn E., Meadows, Stryder M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878194/
https://ncbi.nlm.nih.gov/pubmed/29460088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-018-9602-0
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