A collagen IV–derived peptide disrupts α(5)β(1) integrin and potentiates Ang2/Tie2 signaling

The angiopoietin (Ang)/Tie2 signaling pathway is essential for maintaining vascular homeostasis, and its dysregulation is associated with several diseases. Interactions between Tie2 and α(5)β(1) integrin have emerged as part of this control; however, the mechanism is incompletely understood. AXT107,...

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Udgivet i:JCI Insight
Main Authors: Mirando, Adam C., Shen, Jikui, Silva, Raquel Lima e, Chu, Zenny, Sass, Nicholas C., Lorenc, Valeria E., Green, Jordan J., Campochiaro, Peter A., Popel, Aleksander S., Pandey, Niranjan B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478425/
https://ncbi.nlm.nih.gov/pubmed/30668550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122043
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