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Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli

Gene synthesis services have largely superseded traditional PCR methods for the generation of cDNAs destined for bacterial expression vectors. This, in turn, has increased the application of codon-optimized cDNAs where codons rarely used by Escherchia coli are replaced with common synonymous codons...

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Publicado en:PLoS One
Main Authors: Konczal, Jennifer, Bower, Justin, Gray, Christopher H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478350/
https://ncbi.nlm.nih.gov/pubmed/31013332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215892
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