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Ultra-High Pressure (>30,000 psi) Packing of Capillary Columns Enhancing Depth of Shotgun Proteomic Analyses

Extreme sample complexity is an inherent challenge in shotgun proteomics that positions quality of chromatographic separations as one of the key determinants of attainable proteome coverage. In search of better separations, macroscopic physical characteristics of capillary columns, i.e., length and...

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Bibliographic Details
Published in:Anal Chem
Main Authors: Shishkova, Evgenia, Hebert, Alexander S., Westphall, Michael S., Coon, Joshua J.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478162/
https://ncbi.nlm.nih.gov/pubmed/30179449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b02766
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