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Ultra-High Pressure (>30,000 psi) Packing of Capillary Columns Enhancing Depth of Shotgun Proteomic Analyses

Extreme sample complexity is an inherent challenge in shotgun proteomics that positions quality of chromatographic separations as one of the key determinants of attainable proteome coverage. In search of better separations, macroscopic physical characteristics of capillary columns, i.e., length and...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Shishkova, Evgenia, Hebert, Alexander S., Westphall, Michael S., Coon, Joshua J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478162/
https://ncbi.nlm.nih.gov/pubmed/30179449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b02766
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