TMOD-04. DETERMINING THE NEUROANATOMICAL AND CELLULAR ORIGIN OF BRAFV600E MUTANT CDKN2A DELETED GLIOMAS AND MECHANISMS OF TRANSFORMATION BY BRAFV600E EXPRESSION IN TRANSGENIC MICE

Expression of the constitutively active BRAF(V600E)-mutant kinase occurs in pediatric and predominantly young adult high-grade glioma patients (Cancer Res. 2010, 70:512; Acta Neuropathol. 2011, 121:397). BRAF(V600E) expression frequently coincides with CDKN2A deletion and marks a subgroup of predomi...

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Vydáno v:Neuro Oncol
Hlavní autoři: Sugiarto, Sista, Lerner, Robin G, Reichholf, Brian, McMahon, Martin, James, Charles David, Petritsch, Claudia K
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Pediatric Brain Tumor Models
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477427/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.243
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