DIPG-16. APPLYING THE SIOPE DIPG REGISTRY SURVIVAL PREDICTION TOOL TO SELECT A SURVIVAL EXTENSION TARGET FOR A POWER CALCULATION FOR A NEW TRIAL OF CONVECTION ENHANCED DRUG DELIVERY (CED) OF CARBOPLATIN AND SODIUM VALPROATE IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

INTRODUCTION: In diffuse intrinsic pontine glioma (DIPG) drug resistance is in part due to inadequate penetration of the blood-brain barrier (BBB) by systemically administered drugs. Convection enhanced drug delivery (CED) techniques have been established to bypass the BBB. Trial design to measure e...

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Publicado en:Neuro Oncol
Autores principales: Szychot, Elwira, Collins, Peter, Cassidy, Hanna, Desai, Mohammed, Hyare, Harpreet, Shankar, Ananth, Gill, Steven, van Vuurden, Dannis, van Zanten, Sophie Veldhuijzen, Walker, David
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Diffuse Intrinsic Pontine Glioma (DIPG)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477291/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.037
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