THER-06. PROTEASOME INHIBITION IN PRIMARY MEDULLOBLASTOMA CELL CULTURE AND PATIENT-DERIVED XENOGRAFT MODELS: A POTENTIAL THERAPEUTIC IMPLICATION

Recent research has shown a role of proteasome ubiquitination in medulloblastoma tumorigenesis and proteasome inhibition as a possible therapeutic target. In medulloblastoma primary cell culture and in a Patched1 haploinsufficiency medulloblastoma mice model, bortezomib, a proteasome inhibitor, has...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Plant, Ashley S, Pulley, Michelle, Di, Kaijun, Goldsmith, Carey, Pathare, Jody, Muhonen, Michael, Loudon, William G, Olaya, Joffre, Bota, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477215/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.213
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