TMOD-08. ELUCIDATING EPIGENETIC MECHANISMS IN DIFFUSE INTRINSIC PONTINE GLIOMA HARBORING ACVR1 G328V AND H3.1 K27M

Diffuse intrinsic pontine glioma (DIPG) is a deadly pediatric brainstem tumor that originates in the pons. Mutations in Activin-A Receptor Type 1 (ACVR1), a bone morphogenetic protein (BMP) receptor, are highly recurrent and specific for DIPG. The ACVR1 mutations co-occur with the H3.1 K27M mutation...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Mendez, Flor, Nunez, Felipe, Kadiyala, Padma, Ravindran, Ramya, Nunez, Fernando, Pawar, Sheeba, Williams, Jessica, Zorrilla-Veloz, Rocío, Swarnam, Umayal, Alcantara, Michelle, Parker, Ethan, Edwards, Marta, Lowenstein, Pedro, Castro, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Pediatric Brain Tumor Models
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477206/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.246
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