GENE-17. GENERATION OF A MOUSE MODEL OF DIFFUSE INTRINSIC PONTINE GLIOMA HARBORING ACVR1 G328V AND H3.1 K27M MUTATIONS

Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brainstem tumor with no efficacious treatment. The most prevalent mutation occurs on the amino terminal tail at Lysine 27 (K27M) resulting in global hypomethylation of H3K27. The H3.1-K27M mutation is highly co-expressed with an acti...

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Publicado no:Neuro Oncol
Main Authors: Mendez, Flor M, Nunez, Felipe J, Koschmann, Carl, Saxena, Meghna, Kamran, Neha, Dzaman, Marta, Pawar, Sheeba, Lowenstein, Pedro R, Castro, Maria G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692739/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.391
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