ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brain tumor, with approximately 25% of DIPGs harboring activating ACVR1 mutations that commonly co-associate with H3.1K27M mutations. Here we show that in vitro expression of ACVR1 R206H with and without H3.1K27M upregulates mesenchym...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hoeman, Christine M., Cordero, Francisco J., Hu, Guo, Misuraca, Katie, Romero, Megan M., Cardona, Herminio J., Nazarian, Javad, Hashizume, Rintaro, McLendon, Roger, Yu, Paul, Procissi, Daniele, Gadd, Samantha, Becher, Oren J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399349/
https://ncbi.nlm.nih.gov/pubmed/30833574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08823-9
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