IMMU-01. NOVEL RNA-TARGETING STRATEGY FOR TREATING T CELL-DRIVEN IMMUNOSUPPRESSION IN HUMAN DIFFUSE INTRINSIC PONTINE GLIOMA

PURPOSE: Our laboratory’s work in adult high-grade glioma has discovered a therapeutically-targetable pathway through the inducible expression of indoleamine 2,3 dioxygenase 1 (IDO1). IDO1 is an immunosuppressive enzyme that metabolizes tryptophan. Our project’s purpose is to delineate the role of T...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Lenzen, Alicia, Lauing, Kristen L, Zhai, Lijie, Ladomersky, Erik, Raman, Pichai, Rathi, Komal, Lulla, Rishi R, Hashizume, Rintaro, Wainwright, Derek A
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Immunology/Immunotherapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477205/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.122
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