THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL SYNERGISTIC COMBINATIONS WITH ENHANCED SAFETY PROFILES FOR THE TREATMENT OF MEDULLOBLASTOMA AND GLIOBLASTOMA

Small molecule inhibitors targeting the BET bromodomain-containing protein BRD4 (BET inhibitors) are in early phase clinical develop for the treatment of several types of cancers, including CNS tumors. Studies have shed increasing insight into their anti-cancer mechanisms of action outside of its cl...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Lam, Fred C, Vu-Han, Tu-Lan, Van de Kooj, Bert, Kong, Yi Wen, Bandopadhayay, Pratiti, Beroukhim, Rameen, Sarkaria, Jann, Hammond, Paula, Yaffe, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Translational Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477191/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.227
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