Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis

Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn’s disease (CD) and ulcerative colitis (UC). Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding affinity of the antibody receptor it encodes, FcγRIIA, for immunoglobulin...

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Pubblicato in:Immunity
Autori principali: Castro-Dopico, Tomas, Dennison, Thomas W., Ferdinand, John R., Mathews, Rebeccah J., Fleming, Aaron, Clift, Dean, Stewart, Benjamin J., Jing, Chenzhi, Strongili, Konstantina, Labzin, Larisa I., Monk, Edward J.M., Saeb-Parsy, Kourosh, Bryant, Clare E., Clare, Simon, Parkes, Miles, Clatworthy, Menna R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477154/
https://ncbi.nlm.nih.gov/pubmed/30876876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.02.006
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