JZTX-V Targets the Voltage Sensor in Kv4.2 to Inhibit I(to) Potassium Channels in Cardiomyocytes

Kv4 potassium channels are responsible for transient outward K(+) currents in the cardiac action potential (AP). Previous experiments by our group demonstrated that Jingzhaotoxin-V (JZTX-V) selectively inhibits A-type potassium channels. However, the specific effects of JZTX-V on the transient outwa...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Zhang, Yiya, Luo, Ji, He, Juan, Rong, Mingqiang, Zeng, Xiongzhi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476928/
https://ncbi.nlm.nih.gov/pubmed/31040778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00357
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