Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

BACKGROUND & AIMS: The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here, we aimed...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Currey, Nicola, Jahan, Zeenat, Caldon, C. Elizabeth, Tran, Phuong N., Benthani, Fahad, De Lacavalerie, Penelope, Roden, Daniel L., Gloss, Brian S., Campos, Claudia, Bean, Elaine G., Bullman, Amanda, Reibe-Pal, Saskia, Dinger, Marcel E., Febbraio, Mark A., Clarke, Stephen J., Dahlstrom, Jane E., Kohonen-Corish, Maija R.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476813/
https://ncbi.nlm.nih.gov/pubmed/30831321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.01.009
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