Reversal of apixaban induced alterations in haemostasis by different coagulation factor concentrates in patients after hip or knee replacement surgery

BACKGROUND: Apixaban is a direct oral anticoagulant (DOAC) with a specific inhibition of activated factor X (FXa). In case of bleeding or need of urgent surgery a direct antidote is not yet available. Off-label application of non-specific haemostatic agents, such as prothrombin complex concentrate (...

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Publicado en:Blood Transfus
Main Authors: Schmidt, Katrin, Krüger, Kerstin, Langer, Elisabeth, Schmutzler, Martin, Johnen, Elke, Wernecke, Klaus D., von Heymann, Christian, Körber, Mareike K.
Formato: Artigo
Idioma:Inglês
Publicado: Edizioni SIMTI - SIMTI Servizi Srl 2019
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6476738/
https://ncbi.nlm.nih.gov/pubmed/29757137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2450/2018.0028-18
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