Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4(+) and CD8(+) T(RM) Cells Associated with Protection against Recurrent Genital Herpes

Reactivation of herpes simplex virus 2 (HSV-2) from latency causes viral shedding that develops into recurrent genital lesions. The immune mechanisms of protection against recurrent genital herpes remain to be fully elucidated. In this preclinical study, we investigated the protective therapeutic ef...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Srivastava, Ruchi, Roy, Soumyabrata, Coulon, Pierre-Gregoire, Vahed, Hawa, Prakash, Swayam, Dhanushkodi, Nisha, Kim, Grace J., Fouladi, Mona A., Campo, Joe, Teng, Andy A., Liang, Xiaowu, Schaefer, Hubert, BenMohamed, Lbachir
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2019
Pynciau:
Vaccines and Antiviral Agents
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475797/
https://ncbi.nlm.nih.gov/pubmed/30787156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02309-18
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