Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4(+) and CD8(+) T(RM) Cells Associated with Protection against Recurrent Genital Herpes

Reactivation of herpes simplex virus 2 (HSV-2) from latency causes viral shedding that develops into recurrent genital lesions. The immune mechanisms of protection against recurrent genital herpes remain to be fully elucidated. In this preclinical study, we investigated the protective therapeutic ef...

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Vydáno v:J Virol
Hlavní autoři: Srivastava, Ruchi, Roy, Soumyabrata, Coulon, Pierre-Gregoire, Vahed, Hawa, Prakash, Swayam, Dhanushkodi, Nisha, Kim, Grace J., Fouladi, Mona A., Campo, Joe, Teng, Andy A., Liang, Xiaowu, Schaefer, Hubert, BenMohamed, Lbachir
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475797/
https://ncbi.nlm.nih.gov/pubmed/30787156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02309-18
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