Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4(+) and CD8(+) T(RM) Cells Associated with Protection against Recurrent Genital Herpes

Reactivation of herpes simplex virus 2 (HSV-2) from latency causes viral shedding that develops into recurrent genital lesions. The immune mechanisms of protection against recurrent genital herpes remain to be fully elucidated. In this preclinical study, we investigated the protective therapeutic ef...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Srivastava, Ruchi, Roy, Soumyabrata, Coulon, Pierre-Gregoire, Vahed, Hawa, Prakash, Swayam, Dhanushkodi, Nisha, Kim, Grace J., Fouladi, Mona A., Campo, Joe, Teng, Andy A., Liang, Xiaowu, Schaefer, Hubert, BenMohamed, Lbachir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475797/
https://ncbi.nlm.nih.gov/pubmed/30787156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02309-18
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