Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that typically occurs in renal surgeries. However, renal I/R still currently lacks effective therapeutic targets. In this study, we proved that inhibition of Brd4 with its selective inhibitor, JQ1, could exer...

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Vydáno v:Redox Biol
Hlavní autoři: Liu, Hao, Wang, Lei, Weng, Xiaodong, Chen, Hui, Du, Yang, Diao, Changhui, Chen, Zhiyuan, Liu, Xiuheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475721/
https://ncbi.nlm.nih.gov/pubmed/31004990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101195
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