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A Practical Approach to Adjusting for Population Stratification in Genome-wide Association Studies: Principal Components And Propensity Scores (PCAPS)

Genome-wide association studies (GWAS) are susceptible to bias due to population stratification (PS). The most widely used method to correct bias due to PS is principal components (PCs) analysis (PCA), but there is no objective method to guide which PCs to include as covariates. Often, the ten PCs w...

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Detalhes bibliográficos
Publicado no:Stat Appl Genet Mol Biol
Main Authors: Zhao, Huaqing, Mitra, Nandita, Kanetsky, Peter A., Nathanson, Katherine L., Rebbeck, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475581/
https://ncbi.nlm.nih.gov/pubmed/30507552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/sagmb-2017-0054
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