Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition

Asymmetric synthesis of the biologically active xanthone dimer griffipavixanthone is reported along with its absolute stereochemistry determination. Synthesis of the natural product is accomplished via dimerization of a p-quinone methide using a chiral phosphoric acid catalyst to afford a protected...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Smith, Michael J., Reichl, Kyle D., Escobar, Randolph A., Heavey, Thomas J., Coker, David F., Schaus, Scott E., Porco, John A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475489/
https://ncbi.nlm.nih.gov/pubmed/30566336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b12520
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