Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP(5+) Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

BACKGROUND: Aortic valve sclerosis (AVSc), the early asymptomatic presentation of calcific aortic valve (AV) disease, affects 25% to 30% of patients aged >65 years. In vitro and ex vivo experiments with antioxidant strategies and antagonists of osteogenic differentiation revealed that AVSc is rev...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Anselmo, Wanda, Branchetti, Emanuela, Grau, Juan B., Li, Gen, Ayoub, Salma, Lai, Eric K., Rioux, Nancy, Tovmasyan, Artak, Fortier, Jacqueline H., Sacks, Michael S., Batinic‐Haberle, Ines, Hazen, Stanley L., Levy, Robert J., Ferrari, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474974/
https://ncbi.nlm.nih.gov/pubmed/30371255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007861
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