Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway

Tubule-interstitial injury (TII) is a critical step in the progression of renal disease. It has been proposed that changes in proximal tubule (PT) albumin endocytosis plays an important role in the development of TII. Some reports have shown protective effects of lithium on kidney injury animal mode...

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Udgivet i:PLoS One
Main Authors: Teixeira, Douglas E., Peruchetti, Diogo B., Silva, Leandro S., Silva-Aguiar, Rodrigo P., Oquendo, Morgana B., Silva-Filho, João Luiz, Takiya, Christina M., Leal-Cardoso, José Henrique, Pinheiro, Ana Acacia S., Caruso-Neves, Celso
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474631/
https://ncbi.nlm.nih.gov/pubmed/31002704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0215871
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