The clinical relevance of multiple DPYD polymorphisms on patients candidate for fluoropyrimidine based-chemotherapy. An Italian case-control study

BACKGROUND: Deleterious polymorphisms in the gene encoding DPD (DPYD) may result in severe reduction of DPD enzymatic activity that causes life-threatening toxicities when the standard dose of fluorouracil is used. The best panel of single-nucleotide polymorphism (SNPs) of DPYD is not well defined....

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Publicat a:Br J Cancer
Autors principals: Iachetta, Francesco, Bonelli, Candida, Romagnani, Alessandra, Zamponi, Raffaella, Tofani, Lorenzo, Farnetti, Enrico, Nicoli, Davide, Damato, Angela, Banzi, Maria, Casali, Bruno, Pinto, Carmine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6474277/
https://ncbi.nlm.nih.gov/pubmed/30858516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0423-8
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