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Effects of muscarinic M(1) and M(4) acetylcholine receptor stimulation on extinction and reinstatement of cocaine seeking in male mice, independent of extinction learning

RATIONALE: Stimulating muscarinic M(1)/M(4) receptors can blunt reinforcing and other effects of cocaine. A hallmark of addiction is continued drug seeking/craving after abstinence, and relapse. OBJECTIVES: We tested whether stimulating M(1) and/or M(4) receptors could facilitate extinction of cocai...

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Publicat a:Psychopharmacology (Berl)
Autors principals: Stoll, Kevin, Hart, Rachel, Lindsley, Craig W., Thomsen, Morgane
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472894/
https://ncbi.nlm.nih.gov/pubmed/29250738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4797-0
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