SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

BACKGROUND: Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and signaling platforms. SCD1 overexpression functions as an oncogene in lung cancer an...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Cell Int
Auteurs principaux: She, Kelin, Fang, Shenghua, Du, Wei, Fan, Xingxing, He, Jiaxi, Pan, Hui, Huang, Liyan, He, Ping, Huang, Jun
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Primary Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472070/
https://ncbi.nlm.nih.gov/pubmed/31019378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0809-y
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