Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination

Isotype switching involves a region-specific, nonhomologous recombinational deletion that has been suggested to occur by nonhomologous joining of broken DNA ends. Here, we find increased donor/acceptor homology at switch junctions from PMS2-deficient mice and propose that class switching can occur b...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ehrenstein, Michael R., Rada, Cristina, Jones, Anne-Marie, Milstein, César, Neuberger, Michael S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11717399/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241525998
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