Hexokinase-II Inhibition Synergistically Augments the Anti-tumor Efficacy of Sorafenib in Hepatocellular Carcinoma

This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Yoo, Jeong-Ju, Yu, Su Jong, Na, Juri, Kim, Kyungmin, Cho, Young Youn, Lee, Yun Bin, Cho, Eun Ju, Lee, Jeong-Hoon, Kim, Yoon Jun, Youn, Hyewon, Yoon, Jung-Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6471302/
https://ncbi.nlm.nih.gov/pubmed/30875800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20061292
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