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Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK

Sorafenib has been approved for the treatment of advanced stage hepatocellular carcinoma but has limited efficacy. Ursodeoxycholic acid exerts cytoprotective activities in hepatocytes and is believed to suppress tumorigenesis through cell cycle arrest and induction of apoptosis. The present study ex...

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Foilsithe in:Int J Mol Med
Main Authors: Lee, Seulki, Cho, Young Youn, Cho, Eun Ju, Yu, Su Jong, Lee, Jeong-Hoon, Yoon, Jung-Hwan, Kim, Yoon Jun
Formáid: Artigo
Teanga:Inglês
Foilsithe: D.A. Spandidos 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192782/
https://ncbi.nlm.nih.gov/pubmed/30106087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3807
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