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Loss of PKM2 in Lgr5(+) intestinal stem cells promotes colitis-associated colorectal cancer
The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed in patients with ulcerative colitis or colorectal cancer (CRC). We then investigated t...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6470145/ https://ncbi.nlm.nih.gov/pubmed/30996297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42707-8 |
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