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α2δ-1–Bound NMDA Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents
BACKGROUND: Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-Methyl-D-aspartate receptor (NMDAR) activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism...
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| Publicado no: | Anesthesiology |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6469992/ https://ncbi.nlm.nih.gov/pubmed/30839350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002648 |
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