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α2δ-1–Bound NMDA Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents

BACKGROUND: Chronic use of μ-opioid receptor agonists paradoxically causes both hyperalgesia and the loss of analgesic efficacy. Opioid treatment increases presynaptic N-Methyl-D-aspartate receptor (NMDAR) activity to potentiate nociceptive input to spinal dorsal horn neurons. However, the mechanism...

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Bibliografiske detaljer
Udgivet i:Anesthesiology
Main Authors: Deng, Meichun, Chen, Shao-Rui, Chen, Hong, Pan, Hui-Lin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469992/
https://ncbi.nlm.nih.gov/pubmed/30839350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002648
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