Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells

The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here we describe three ER-resident proteins (Aster-A, -B, -C) that bind cholesterol and faci...

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Vydáno v:Cell
Hlavní autoři: Sandhu, Jaspreet, Li, Shiqian, Fairall, Louise, Pfisterer, Simon G., Gurnett, Jennifer E., Xiao, Xu, Weston, Thomas A., Vashi, Dipti, Ferrari, Alessandra, Orozco, Jose L., Hartman, Celine L., Strugatsky, David, Lee, Stephen D., He, Cuiwen, Hong, Cynthia, Jiang, Haibo, Bentolila, Laurent A., Gatta, Alberto T., Levine, Tim P., Ferng, Annie, Lee, Richard, Ford, David A., Young, Stephen G., Ikonen, Elina, Schwabe, John W.R., Tontonoz, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469685/
https://ncbi.nlm.nih.gov/pubmed/30220461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.033
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