Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells

The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here we describe three ER-resident proteins (Aster-A, -B, -C) that bind cholesterol and faci...

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Publicado no:Cell
Main Authors: Sandhu, Jaspreet, Li, Shiqian, Fairall, Louise, Pfisterer, Simon G., Gurnett, Jennifer E., Xiao, Xu, Weston, Thomas A., Vashi, Dipti, Ferrari, Alessandra, Orozco, Jose L., Hartman, Celine L., Strugatsky, David, Lee, Stephen D., He, Cuiwen, Hong, Cynthia, Jiang, Haibo, Bentolila, Laurent A., Gatta, Alberto T., Levine, Tim P., Ferng, Annie, Lee, Richard, Ford, David A., Young, Stephen G., Ikonen, Elina, Schwabe, John W.R., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469685/
https://ncbi.nlm.nih.gov/pubmed/30220461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.033
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