Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

RATIONALE: Hyperglycemia accelerates the progression of Alzheimer’s disease (AD), and GSK3β plays a potential link between AD and hyperglycemia. Therefore, a direct or indirect GSK3β inhibition may have potential to delay the progression of AD. Our previous biochemical assay identified AM404 as a GS...

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Bibliografische gegevens
Gepubliceerd in:Psychopharmacology (Berl)
Hoofdauteurs: Huang, Hei-Jen, Chen, Shu-Ling, Huang, Hsin-Yu, Sun, Ying-Chieh, Lee, Guan-Chiun, Lee-Chen, Guey-Jen, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2018
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Original Investigation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469654/
https://ncbi.nlm.nih.gov/pubmed/30426182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-5108-0
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