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Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference collaborate to down-regulate protein expression. Developmentally timed transcriptional interference inhibited production of a well translated mRNA isoform and resu...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Hollerer, Ina, Barker, Juliet C., Jorgensen, Victoria, Tresenrider, Amy, Dugast-Darzacq, Claire, Chan, Leon Y., Darzacq, Xavier, Tjian, Robert, Ünal, Elçin, Brar, Gloria A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469420/
https://ncbi.nlm.nih.gov/pubmed/30723103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.118.200802
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