Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells

We recently described an unconventional mode of gene regulation in budding yeast by which transcriptional and translational interference collaborate to down-regulate protein expression. Developmentally timed transcriptional interference inhibited production of a well translated mRNA isoform and resu...

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Vydáno v:G3 (Bethesda)
Hlavní autoři: Hollerer, Ina, Barker, Juliet C., Jorgensen, Victoria, Tresenrider, Amy, Dugast-Darzacq, Claire, Chan, Leon Y., Darzacq, Xavier, Tjian, Robert, Ünal, Elçin, Brar, Gloria A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2019
Témata:
Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6469420/
https://ncbi.nlm.nih.gov/pubmed/30723103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.118.200802
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