Nicotine Induces Resistance to Erlotinib Therapy in Non-Small-Cell Lung Cancer Cells Treated with Serum from Human Patients

Previously, we reported that nicotine reduces erlotinib sensitivity in a xenograft model of PC9, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-sensitive non-small-cell lung cancer cell line. The present study examined whether smoking induces erlotinib resistance in vitro....

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Imabayashi, Tatsuya, Uchino, Junji, Osoreda, Hisayuki, Tanimura, Keiko, Chihara, Yusuke, Tamiya, Nobuyo, Kaneko, Yoshiko, Yamada, Tadaaki, Takayama, Koichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468898/
https://ncbi.nlm.nih.gov/pubmed/30818860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030282
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