Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in PARK2, coding for parkin, which plays an important role in mitochondria function and calcium homeostasis. Cyclic adenosine monophosphate (cAMP) is a major second messenger regulating mitochondrial metab...

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Publicat a:Cells
Autors principals: Tanzarella, Paola, Ferretta, Anna, Barile, Simona Nicol, Ancona, Mariella, De Rasmo, Domenico, Signorile, Anna, Papa, Sergio, Capitanio, Nazzareno, Pacelli, Consiglia, Cocco, Tiziana
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468892/
https://ncbi.nlm.nih.gov/pubmed/30875974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8030250
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