Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in PARK2, coding for parkin, which plays an important role in mitochondria function and calcium homeostasis. Cyclic adenosine monophosphate (cAMP) is a major second messenger regulating mitochondrial metab...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cells
Hauptverfasser: Tanzarella, Paola, Ferretta, Anna, Barile, Simona Nicol, Ancona, Mariella, De Rasmo, Domenico, Signorile, Anna, Papa, Sergio, Capitanio, Nazzareno, Pacelli, Consiglia, Cocco, Tiziana
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468892/
https://ncbi.nlm.nih.gov/pubmed/30875974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8030250
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge