Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types

Dysfunctional homologous recombination DNA repair (HRR), frequently due to BRCA mutations, is a determinant of sensitivity to platinum chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi). In cultures of ovarian cancer cells, we have previously shown that HRR function, based upon RAD51 fo...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Gentles, Lucy, Goranov, Bojidar, Matheson, Elizabeth, Herriott, Ashleigh, Kaufmann, Angelika, Hall, Sally, Mukhopadhyay, Asima, Drew, Yvette, Curtin, Nicola J., O’Donnell, Rachel L
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468835/
https://ncbi.nlm.nih.gov/pubmed/30871186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030354
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