Staphylococcus aureus leukocidins target endothelial DARC to cause lethality in mice

The pathogenesis of Staphylococcus aureus is thought to depend on the production of pore-forming leukocidins that kill leukocytes and lyse erythrocytes. Two leukocidins, Leukocidin ED (LukED) and γ-Hemolysin AB (HlgAB), are necessary and sufficient to kill mice upon infection and toxin challenge. We...

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Bibliografske podrobnosti
izdano v:Cell Host Microbe
Main Authors: Lubkin, Ashira, Lee, Warren L., Alonzo, Francis, Wang, Changsen, Aligo, Jason, Keller, Matthew, Girgis, Natasha M., Reyes-Robles, Tamara, Chan, Rita, O’Malley, Aidan, Buckley, Peter, Vozhilla, Nikollaq, Vasquez, Marilyn T., Su, Johnny, Sugiyama, Michael, Yeung, Stephen T., Coffre, Maryaline, Bajwa, Sofia, Chen, Eric, Martin, Patricia, Kim, Sang Y., Loomis, Cynthia, Worthen, G. Scott, Shopsin, Bo, Khanna, Kamal M., Weinstock, Daniel, Lynch, Anthony Simon, Koralov, Sergei B., Loke, P’ng, Cadwell, Ken, Torres, Victor J.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468323/
https://ncbi.nlm.nih.gov/pubmed/30799265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.01.015
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