Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors

The proper tissue-specific regulation of gene expression is essential for development and homeostasis in metazoans. However, the illegitimate expression of normally tissue-restricted genes—like testis- or placenta-specific genes—is frequently observed in tumors; this promotes transformation, but als...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Naciri, Ikrame, Laisné, Marthe, Ferry, Laure, Bourmaud, Morgane, Gupta, Nikhil, Di Carlo, Selene, Huna, Anda, Martin, Nadine, Peduto, Lucie, Bernard, David, Kirsh, Olivier, Defossez, Pierre-Antoine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468300/
https://ncbi.nlm.nih.gov/pubmed/30753595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz080
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