MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis

Myogenic regulatory factors of the MyoD family have the ability to reprogram differentiated cells toward a myogenic fate. In this study, we demonstrate that Six1 or Six4 are required for the reprogramming by MyoD of mouse embryonic fibroblasts (MEFs). Using microarray experiments, we found 761 genes...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Santolini, Marc, Sakakibara, Iori, Gauthier, Morgane, Ribas-Aulinas, Francesc, Takahashi, Hirotaka, Sawasaki, Tatsuya, Mouly, Vincent, Concordet, Jean-Paul, Defossez, Pierre-Antoine, Hakim, Vincent, Maire, Pascal
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062961/
https://ncbi.nlm.nih.gov/pubmed/27302134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw512
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