Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair

UV light induces cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PPs), which can result in carcinogenesis and aging, if not properly repaired by nucleotide excision repair (NER). Assays to determine DNA damage load and repair rates are invaluable tools for fund...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Steurer, Barbara, Turkyilmaz, Yasemin, van Toorn, Marvin, van Leeuwen, Wessel, Escudero-Ferruz, Paula, Marteijn, Jurgen A
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468286/
https://ncbi.nlm.nih.gov/pubmed/30698791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz035
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